An enormous variety of special building blocks exist that can be used for SPPS. Particularly, the influence of the side chain can be studied by replacing a natural amino acid by such special building blocks.
BIOSYNTAN has great experience in synthesizing peptides modified with such building blocks. In order to match the special needs of your scientific questions, please see the following selection, BIOSYNTAN has already worked with.
Furthermore, BIOSYNTAN offers the synthesis of peptides with special building blocks, provided by our customers. Please, feel free to discuss your wishes with us.
- Aspartic & Glutamatic acid analogs
(iso-Asp, iso-Glu, pGlu)
- Cysteine & Methionine analogs
(Met(O), Seleno-Cys/Met, Penicillamine)
- Lysine & Arginine analogs
(Methylation, Acetylation, Biotin, TFA, Palmitoylation, Orn, Dab, Dap, Cit)
- Phenylalanine, Tyrosine & Tryptophane analogs
(Phe(NH2), Phe(F), Phe(CF3), Phe(Guanidino), Phe(Aminomethyl), Tyr(NO2), Tyr(Cl), Trp(F), Trp(Me))
- Proline analogs
(Hyp, Pro(F), Pro(NH2))
- Hydrophobic amino acids
(ß-Ala, Ahx, Nva, Nle, tertLeu, Cha, Abu, Aib, Nal, Bpa)
- Homo amino acids & N-methyl amino acids
- Activated Cysteine analogs
(Cys(Pys), Cys(NPys), Bunte salt)
- PEG building blocks
- Fatty acids & Carboxylic acids
- Special Linker