The modification of peptides with carboxylic or fatty acids increases solubility in unpolar solvents and affinity to cell membranes. Additionally, such peptides can be used to modulate the surface of vesicles.
The modification of peptides with cholesterol or farnesyl represent different ways to increase the hydrophobicity of a peptide. Typically, cholesterol is coupled as hemisuccinate to amino groups. In contrast, farnesyl is attached to the thiol group of cysteine.
For any other modification with special carboxylic acids, fell free to discuss your wishes with us.