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# Biosyntan GmbH

Custom Peptide Synthesis

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- [HOME](https://biosyntan.com/) - BIOSYNTAN - High quality custom peptide synthesis. Standard, modified and fluorescent peptide synthesis combined with excellent service and expert advice.
- [Terms & Conditions (AGB) / Terms and Conditions](https://biosyntan.com/about-biosyntan/terms-conditions-agb-terms-and-conditions/) - Allgemeine Geschäftsbedingungen (AGB) Grundsatz Die nachstehenden Bedingungen gelten für alle Verträge, die mit der Biosyntan GmbH (im weiteren Biosyntan genannt) über den Kauf von Waren und Dienstleistungen geschlossen wurden, falls kein anderslautender, schriftlicher Vertrag vorliegt. Mit der Erteilung des Auftrages erkennt der Käufer ausschließlich die nachstehenden Bedingungen an. Die Einkaufsbedingungen des Käufers haben keine Gültigkeit,
- [Search](https://biosyntan.com/additional-services/search/)
- [Immunogenic Peptides](https://biosyntan.com/additional-services/immunogenic-peptides/) - Immunogenic Peptides We synthesize components for epitope mapping and immunization: Prediction and selection of epitopes Peptide conjugates (KLH, BSA, etc.) Multiple antigenic peptides (MAPs) Screening peptides Immunogenic Peptides for Screening Purposes and Epitope Mapping For the B- and T-cell epitope mapping, but also for other scientific questions, a lot of peptides are needed only in minor
- [Additional Services](https://biosyntan.com/additional-services/)
- [Phosphorylation](https://biosyntan.com/modified-peptides/phosphorylation/) - Phosphorylation is one of the most frequently occurring post-translational modifications. BIOSYNTAN offers phosphorylation at serine, threonine and tyrosine.
- [Native Chemical Ligation](https://biosyntan.com/modified-peptides/peptides-for-ligation/native-chemical-ligation/) - Native Chemical Ligation Introduced in 1994 by S. B. Kent, Native Chemical Ligation (NCL) is the most popular of the ligation reactions, particularly for the chemical synthesis of longer peptides or even proteins. The two necessary components are a C-terminal peptide thioester and an N-terminal cysteine. Both react via a transthioesterification step in order to form a
- [Click Chemistry](https://biosyntan.com/modified-peptides/peptides-for-ligation/click-chemistry/) - Biosyntan offers peptides with different azide or alkyne building blocks that can be incorporated at any position.
- [Peptides for Ligation](https://biosyntan.com/modified-peptides/peptides-for-ligation/) - Click chemistry and NCL are the most prominent of the ligations reactions. BIOSYNTAN offers peptides for ligation that contain all necessary components.
- [Spin Labels](https://biosyntan.com/modified-peptides/labeled-peptides/spin-labels/) - Spin labeling of peptides plays an important role in the investigation of protein interactions by NMR. BIOSYNTAN offers two different types of spin labels.
- [Photo Cross Linkers](https://biosyntan.com/modified-peptides/labeled-peptides/photo-cross-linkers/) - Photo cross linkers are a helpful tool for the investigation of peptide-protein interactions. Irradiation by UV-light creates a stable covalent bond between the interaction partners.
- [Isotope Labels](https://biosyntan.com/modified-peptides/labeled-peptides/isotope-labels/) - BIOSYNTAN offers peptides with a broad spectrum of isotope labeled amino acids. Such isotope labels can be incorporated at any desired position.
- [Chelators](https://biosyntan.com/modified-peptides/labeled-peptides/chelators/) - Labeled peptides with radioactive or heavy metals furnishes a very powerful tool for imaging assays. For this purpose chelators are a necessary modification.
- [Labeled Peptides](https://biosyntan.com/modified-peptides/labeled-peptides/) - BIOSYNTAN offers peptide synthesis with different labels matching various research issues: chelators, photo cross linkers or isotopic or spin labeling.
- [Glycosylation](https://biosyntan.com/modified-peptides/glycosylation/) - Glycosylation Glycosylation represents another important type of post-translational modification. Glycans serve a variety of structural and functional roles in membranes and secreted proteins. Generally, serine, threonine, and asparagine residues are suitable amino acids for glycosylation. BIOSYNTAN offers various types of glycosyl-residues at those amino acids. An overview is presented in the following table. For
- [D-Amino Acids](https://biosyntan.com/modified-peptides/d-amino-acids/) - D-Amino Acids Opposite stereochemistry in the α-position of essential amino acids produces interesting new features. Firstly, D-amino acids increase the stability of peptides against proteases. Secondly, they can create special secondary structures, e.g. turn structures. BIOSYNTAN is able to incorporate any D-amino acid in your peptide corresponding to the set of essential amino acids.
- [Side Chain Cyclization](https://biosyntan.com/modified-peptides/cyclization-disulfides/side-chain-cyclization/) - Side Chain Cyclization In this type of cyclization a stable amide bond is formed between a side chain carboxyl group of aspartic acid or glutamic acid and an amino group of lysine. Homologues of these amino acids can be chosen as well. The minimum length of the peptide should be in this case at least
- [Disulfides](https://biosyntan.com/modified-peptides/cyclization-disulfides/disulfides/) - BIOSYNTAN offers peptides with intermolecular and interamolecular disulfides as well as peptides with up to 3 disulfide bonds in a defined connection pattern.
- [Modified Peptides](https://biosyntan.com/modified-peptides/) - Modified Peptides Beyond the standard peptides, BIOSYNTAN offers custom synthesis of peptides with a huge variety of modifications, including posttranslational modifications, incorporation of special building blocks, cyclic peptides and disulfides, label for various purposes and activated peptides for ligation reactions. Post-translational Modifications Phosphorylation Glycosylation Biotinylation Methylation Acetylation Sulfation Special Building Blocks D-Amino acids Apartic & glutamic acid analogs Cysteine & methionine
- [Special Building Blocks](https://biosyntan.com/modified-peptides/special-building-blocks/) - Special Building Blocks An enormous variety of special building blocks exists that can be used for SPPS. Particularly, the influence of the side chain can be studied by replacing a natural amino acid by such special building blocks. BIOSYNTAN has great experience in synthesizing peptides modified with such building blocks. In order to match the
- [Cysteine & Methionine Analogs](https://biosyntan.com/modified-peptides/special-building-blocks/cysteine-methionine-analogs/) - Cysteine & Methionine Analogs
- [Fatty Acids & Carboxylic Acids](https://biosyntan.com/modified-peptides/special-building-blocks/fatty-acids-carboxylic-acids/) - Fatty Acids & Carboxylic Acids The modification of peptides with carboxylic or fatty acids increases solubility in unpolar solvents and affinity to cell membranes. Additionally, such peptides can be used to modulate the surface of vesicles. Fatty acids as well as dicarboxylic acids can be coupled to any amino group present in the peptide. The modification of peptides
- [Homo Amino Acids & N-Methyl Amino Acids](https://biosyntan.com/modified-peptides/special-building-blocks/homo-amino-acids-n-methyl-amino-acids/) - Homo Amino Acids & N-Methyl Amino Acids
- [Hydrophobic Amino Acids](https://biosyntan.com/modified-peptides/special-building-blocks/hydrophobic-amino-acids/) - Hydrophobic Amino Acids
- [Lysine & Arginine Analogs](https://biosyntan.com/modified-peptides/special-building-blocks/lysine-arginine-analogs/) - Lysine & Arginine Analogs
- [PEG building blocks](https://biosyntan.com/modified-peptides/special-building-blocks/peg-building-blocks/) - PEG building blocks PEG building blocks are used in many cases as a spacer. Due to their hydrophilic nature, PEG residues can improve the solubility of peptides. Additionally, certain protection against proteases is discussed as well. BIOSYNTAN synthesizes peptides with defined PEG building blocks, which are depicted in the list below.
- [Phenylalanine, Tyrosine & Tryptophane Analogs](https://biosyntan.com/modified-peptides/special-building-blocks/phenylalanine-tyrosine-tryptophane-analogs/) - Phenylalanine, Tyrosine & Tryptophane Analogs
- [Sulfation](https://biosyntan.com/modified-peptides/sulfation/) - Sulfation of peptides is another post-translational modification. BIOSYNTAN offers sulfated versions of tyrosine, serine and threonine.
- [Proline Analogs](https://biosyntan.com/modified-peptides/special-building-blocks/proline-analogs/) - BIOSYNTAN offers peptides with various proline analogs, e.g. 3- or 4-hydroxy proline, 4-fluoro proline or 4-amino proline.
- [Antibodies](https://biosyntan.com/additional-services/antibodies/) - Antibodies Together with our cooperation partner BioGenes GmbH we offer the following services: Conjugation of haptens to carrier proteins Polyclonal antibodies Monoclonal antibodies Assay development Expert advice and problem solving
- [Coupling of Peptides to Dye-encoded Beads](https://biosyntan.com/additional-services/coupling-of-peptides-to-dye-encoded-beads/) - Together with our cooperation partner PolyAn GmbH we offer coupling of peptides to dye-encoded beads for multiplex analysis
- [Hapten Modification & Coupling](https://biosyntan.com/additional-services/hapten-modification-coupling/) - Hapten Modification & Coupling Many scientific objectives, including immunoassay development of non-peptidic structures require chemical modification and derivatization of organic molecules as well as their analytical characterization, aiming at their capability to couple e.g. to carrier proteins. For this purpose we offer chemical synthesis service in the context of Hapten modification Hapten coupling
- [Peptide Research](https://biosyntan.com/additional-services/peptide-research/) - Beyond custom synthesis, BIOSYNTAN was and is currently involved in several peptide research projects. If you are looking for a project partner in the field of peptide chemistry, BIOSYNTAN is very open for future cooperations.
- [Technical Library](https://biosyntan.com/additional-services/technical-library/) - Our Technical Labrary contains valuable knowledge about technical questions, e.g. solubilization problems, the correct calculation of the molecular weight etc.
- [Imprint / Impressum](https://biosyntan.com/about-biosyntan/imprint-impressum/) - Imprint / Impressum (Angaben gemäß § 5 TMG) Kontakt Biosyntan GmbHRobert-Rössle-Str. 1013125 Berlin Telefon: +49 (0)30 94893498Telefax: +49 (0)30 94893497 E-Mail: biosyntan@biosyntan.de Vertreten durch Dr. Stephan Pritz Jacqueline Dalski Registereintrag Eintragung im Handelsregister. Registergericht: Berlin-CharlottenburgRegisternummer: HRB 65561 Umsatzsteuer-ID Umsatzsteuer-Identifikationsnummer gemäß §27 a Umsatzsteuergesetz: DE 191 429 095 Webseiteninhalte Biosyntan GmbH - Dr. Kai
- [Company profile](https://biosyntan.com/about-biosyntan/company-profile/) - Company Profile. BIOSYNTAN GmbH was founded in 1997 as a scientific service company, focused on custom synthesis of peptides.
- [About Biosyntan](https://biosyntan.com/about-biosyntan/)
- [Job offers](https://biosyntan.com/about-biosyntan/job-offers/) - Job offers There are currently no job offers available.
- [Synthesis of Standard Peptides](https://biosyntan.com/standard-peptides/synthesis-of-standard-peptides/) - Synthesis of Standard Peptides BIOSYNTAN offers automated custom synthesis of standard peptides up to 100 residues on a scale of 1-500 mg, purification (standard purities: 80% or 95%) and analysis of all products by HPLC and mass spectrometry. We have excellent expertise in synthesizing fluorescently labeled peptides, protease and kinase substrates, and histone peptides.
- [Spacer](https://biosyntan.com/standard-peptides/n-and-c-terminal-derivatization-2/spacer/) - BIOSYNTAN offers PEG and Ahx spacer in order to modify the distance between labels and epitopes, or to increase the solubility of your peptide.
- [N-terminal Derivatization](https://biosyntan.com/standard-peptides/n-and-c-terminal-derivatization-2/n-terminal-derivatization/) - N-terminal Derivatization Our N-terminal derivatization portfolio includes: acetylation, formylation, palmitoylation, alkylation and many types more.
- [NEDD8 & Derivatives](https://biosyntan.com/ubiquitin-derivatives-2/nedd8-derivatives/) - BIOSYNTAN offers NEDD8 and fluorescently labeled derivatives in high quality. BIOSYNTAN provides quantities up to 10 mg in 90% purity.
- [Ubiquitin & Derivatives](https://biosyntan.com/ubiquitin-derivatives-2/) - BIOSYNTAN offers ubiquitin and fluorescently labeled derivatives in very high quality. BIOSYNTAN provides quantities up to 100 mg.
- [Requests & Orders](https://biosyntan.com/requests-orders/) - We will be happy to advise you on the design of your peptides. For requests and questions, you can send us an email to biosyntan@biosyntan.de.
- [SARS-CoV-2 Main Protease Substrate](https://biosyntan.com/fluorescent-peptides/fluorescent-labeling-of-peptides/sars-cov-2-substrates/) - BIOSYNTAN offers a fluorogenic FRET substrate as well as a rhodamine substrate for activity determination and inhibitor screening of SARS-Cov-2 Mpro protease.
- [DYOMICS-Label](https://biosyntan.com/fluorescent-peptides/fluorescent-labeling-of-peptides/dyomics-label/) - To cover the entire spectrum of visible and IR light, Biosyntan recommends DYOMICS-label, which are comparable to Alexa Fluor® and other dyes in any manner.
- [Fluorescent Labeling of Peptides](https://biosyntan.com/fluorescent-peptides/fluorescent-labeling-of-peptides/) - BIOSYNTAN has gained great expertise in fluorescent labeling of peptides. Our portfolio includes various fluorescent labels and different labeling techniques.
- [Standard Fluorescence Label](https://biosyntan.com/fluorescent-peptides/standard-fluorescence-label/) - BIOSYNTAN offers labeling of peptides with fluorescein and rhodamine dyes, cyaine and BODIPY dyes as well as coumarin based dyes.
- [Rhodamine 110 Label](https://biosyntan.com/fluorescent-peptides/rhodamine-110-label/) - Rhodamine 110 Label Rhodamine 110 proved to be a very suitable label for fluorescent protease assays. The red-shifted excitation (492nm) and emission (529nm) shows better signal-to-noise ratio and produces less interference with potential inhibitors in screening assays. This leads up to a 300-fold higher sensitivity when compared with AMC substrates. Symmetric & Asymmetric Rhodamine 110
- [FRET Systems](https://biosyntan.com/fluorescent-peptides/fret-systems/) - FRET Systems Peptides labeled with FRET systems are often used in fluorescent protease assays. In this system, a protease substrate is labeled at two positions with a corresponding FRET pair. Upon proteolytic cleavage, the FRET partners are separated and the FRET effect is suppressed. Fluorescence is generated (A: in case of a quencher) or shifted
- [Backbone Cyclization](https://biosyntan.com/modified-peptides/cyclization-disulfides/backbone-cyclization/) - Backbone Cyclization A stable amide bond is formed between the C-terminal carboxyl group and the N-terminal amino group. The minimum length of the peptide should be at least 5 amino acids for a backbone cyclization. No limits are set for the maximum length. However, the cyclization becomes more challenging as the number of amino acids
- [Cyclization & Disulfides](https://biosyntan.com/modified-peptides/cyclization-disulfides/) - Cyclization & Disulfides Cyclic peptides exhibit interesting features compared to the linear species: such peptides are remarkably stable against degradation by proteases. Furthermore, they can present a certain amino acid motif in a rigidified structure. This property can be essential for the recognition of some hormones by their receptors. There are different ways known to
- [Biotinylation](https://biosyntan.com/modified-peptides/biotinylation/) - Biotinylation The extraordinary strong interaction of biotin and avidin/streptavidin is used for plenty of different applications in biochemistry. Biotin derivatization of peptides generates a very useful tool for immobilization in ELISA-assays, detection by specific antibodies, or affinity purification of peptides. BIOSYNTAN offers three different types of biotin labeling. In case of functional assays, a spacer
- [C-terminal Derivatization](https://biosyntan.com/standard-peptides/n-and-c-terminal-derivatization-2/c-terminal-derivatization/) - C-terminal Derivatization Our C-terminal derivatization portfolio includesAlkyl amides at the C-terminus of a peptide block or slow enzymatic digestion. C-terminal peptide hydrazides can easily be turned into azides, which can subsequently be used in ligation reactions. Peptide hydroxamates are suitable tools for ligation reactions with aldehydes. Alkyl amides at the C-terminus of a peptide block
- [N- and C-terminal Derivatization](https://biosyntan.com/standard-peptides/n-and-c-terminal-derivatization-2/) - N- and C-terminal Derivatization For many biochemical assays, specially derivatized peptides are required. BIOSYNTAN has excellent expertise in the synthesis of such peptides and offers a great variety of modifications. N-terminal derivatization(acetylation, formylation, palmitoylation, alkylation, …) C-terminal derivatization(hydrazides, hydroxamates, methyl esters, alkyl amides, cysteamine, thioesters, EDA- or PEG-labels, …) Biotinylation(N-terminal, C-terminal as EDA-biotin or Lys(biotin)-amide, desthiobiotin)
- [Standard Peptides](https://biosyntan.com/standard-peptides/)
- [Fluorescent Peptides](https://biosyntan.com/fluorescent-peptides/)
- [Contact](https://biosyntan.com/contact/) - Contact Please contact us if you have any questions. Mailing address: BIOSYNTAN GmbHRobert-Rössle-Strasse 1013125 BerlinGermany Phone: +49 30 - 94 89 34 98Fax: +49 30 - 94 89 34 97e-Mail: biosyntan@biosyntan.de You can find us at the research campus Berlin-Buch Building D85, Level A2 General manager: Jacqueline Dalski Dr. Stephan Pritz USt-Id (VAT-No.): DE 191 429 095 HRB-Nummer: 65561
- [Activated Cysteine Analogs](https://biosyntan.com/modified-peptides/special-building-blocks/activated-cysteine-analogs/) - Activated Cysteine Analogs BIOSYNTAN offers peptides with pre-activated cysteine building blocks. Such pre-activated cysteine residues are excellent precursors for the formation of disulfide bonds.
- [Aspartic & Glutamic Acid Analogs](https://biosyntan.com/modified-peptides/special-building-blocks/aspartic-glutamic-acid-analogs/) - Aspartic & Glutamic Acid Analogs
- [Cl-Acetyl/Br-Acetyl/Maleimido Linker](https://biosyntan.com/modified-peptides/special-building-blocks/cl-acetyl-br-acetyl-maleimido-linker/) - Cl-Acetyl/Br-Acetyl/Maleimido Linker Activated linkers are suitable tools to couple peptides to thiol groups of proteins or surfaces. BIOSYNTAN offers the following linkers for such purposes: In contrast to disulfide bridges, these linkers form a redox-stable thioether bond.
- [Fluorescently Labeled Protease Substrates](https://biosyntan.com/fluorescent-peptides/fluorescently-labeled-protease-substrates/) - Fluorescently Labeled Protease Substrates Coumarin Based Substrates Typically, fluorescence-based protease assays use peptide amidomethylcoumarin derivatives as substrates. The non-fluorescent substrate liberates a fluorescent coumarin upon proteolytic cleavage. BIOSYNTAN offers custom tailored substrates with different coumarin based fluorogenic labels. Rhodamine Based Substrates Colored components interfere with fluorescence measurements, resulting in high background noise and reduced sensitivity. This is